Rejection of stable cultured allografts by active or passive (adoptive) immunization.

Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

INTRODUCTION Interleukin-6 (IL-6) is a pleiotropic cytokine for which preliminary data have suggested that it might contribute to systemic sclerosis (SSc). Our aims were to investigate, firstly, IL-6 expression in patients with SSc and, secondly, the efficacy of both passive and active immunization against IL-6 to reduce skin fibrosis in complementary mouse models of SSc. METHODS Human serum ...

Active and Passive Immunization in Typhus Fever.

Inspection of the paleontologic history of many phyla shows that when certain members of a series of polyisomeres have been subjected to in-. creasing stresses through long periods of geologic time, they have often become enlarged, strengthened or fused with their neighbors and have thereby passed into a state of anisomerism. Thus taxonomy, paleontology, comparative anatomy, genetics, experimen...

Active Immunization of Cattle with Killed Vaccines Prepared from Cell Cultured Rinderpest Virus

Rejection of Ascites Tumor Allografts

A pathway for cell-mediated tumor destruction in vitro by immune peritoneal exudate lymphoid cells has been proposed. The union of lymphocytes and tumor cells precedes the formation of an intermediate phase leading to lysis. The initial interaction is only partially temperature dependent. The cytolytic process per se is highly temperature dependent, being negligible at 25 degrees C but proceedi...

Humoral rejection of organ allografts.

In recent years, the deleterious clinical consequences of recipient de novo alloantibody production against HLA antigens from human organ allografts have been extensively investigated. In kidney transplantation, the identification of the complement C4d fragment in peritubular capillaries as a specific marker for humoral rejection has helped to define and characterize distinct clinical alloantib...